EFFCT OF POLYSACCHARIDE FROM THE SPIRULINA PLATENSIS CULTIVATED IN CHINA'S YUNNAN PROVINCE ON THE D-GALACTOSE AGING MODEL MICE
- VernacularTitle:云南产钝顶螺旋藻多糖对D-半乳糖所致衰老小鼠的作用
- Author:
Shaoyuan ZUO
;
Zhenyu ZHU
;
Jianquan MA
- Publication Type:Journal Article
- Keywords:
polysaccharide of Spirulina platensis (PSP);
D-galactose induced aging model;
anti-aging
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
With the dose of D-galactose 80mg/kg by sc administration to the female NIH mice for 6 weeks,the sub-acute aging model was established. In order to observe the effect of the polysaccharide (PSP) on anti-aging, the mice were received PSP 200mg/kg^ 100mg/kg respectively by ig administration at the same time of injection D-galactose. It was found that PSP could remarkably antagonise the effect of D-galactose on the mice. The results showed that PSP could significantly(1)decrease the content of MDA in heart,liver and brain of the mice;(2)increase the SOD activity of RBCJiver and brain in the mice;(3)increase the GSH-Px activity and GSH content of the blood and liver of the mice; (4)inhibit the MAO-B activity of liver and brain in the mice;(5)increase the hydroxyproline content of dermal tissue in aging model mice. In short,it is suggested that PSP could obviously improve the aging effect of D-galactose on the mice.
