STUDIES ON THE CHEMICAL COMPOSITION AND AN-TITUMOR ACTIVITY OF THE GLYCOPROTEIN FROM CHLAMYS (AZUMAPECTEN)FARRERI
- VernacularTitle:扇贝糖蛋白的化学组成与抗肿瘤活性的研究
- Author:
Qianqun GU
;
Yuchun FANG
;
Changyun WANG
- Publication Type:Journal Article
- Keywords:
Chlamys(Azumapecten)farreri;
glycoprotein;
chemical composition;
anti-tumor activity
- From:
Chinese Journal of Marine Drugs
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Glycoprotein of Chlamys ( Azumapecten ) farreril ( GCFI) was prepared from the skirt of scallop Chlamys (Azumapecten)farreri by extraction with hot water,isolation and purification with column chromatography "on DEAE-cellulose and Sephadex G-100 successively. GCFI was hydrolyzes with enzymes to obtain glycoprotein of Chlamys (Azumapecten)farreri IKGCFID-The chemical composition and antitumor activity of GCFI and GCFII were studied. The result showed that GCFI and GCFII were two glycoproteins in which the composition and content of protein and sugar were different. They could obviously inhibit Sarcoma 180 cells proliferation of mice with the inhibition rate of 47. 29% and 46. 97%,respectively. Pharmacological test indicated that antitumor activity of GCFI and GCFII were associated with the structure of sugar in the molecules.
