Primary Safety Assessment of EPO Gene Therapy
- VernacularTitle:EPO基因治疗安全性的初步评价
- Author:
Yongxue LIU
;
Handong WEI
;
Chengkui QU
- Publication Type:Journal Article
- Keywords:
EPO;
gene therapy;
retrovirus;
safety
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The safety of hEPO gene therapy was assessed. No env gene of retrovirus was detected in the EPO-transgenic myoblasts and fibroblasts by PCR detection. Malignant transformation of transgenic cells was ruled out by various examinations including cell morphology, chromosome karyotype, soft-agar test, nude mice test and pathology. All the assessments primarily demonstrated that EPO gene therapy mediated by retrovirus was safe.
