Anti- Tumor Effect of Vaccination with Irradiation Tumor Cells Transduced with Mouse Interferon-Gamma Gene
- VernacularTitle:小鼠?-干扰素基因修饰瘤苗的抗肿瘤研究
- Author:
Zhenyu WU
;
Shishu CHEN
- Publication Type:Journal Article
- Keywords:
RT-PCR;
retroviral vector;
hepatoma cancer;
mouse interferon-gamma;
tumor vaccine;
gene therapy
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The whole length mouse interferon-gamma (mIFN-?) cDNA was obtained using RT-PCR and was introduced into mouse hepatoma cell line H22 by retroviral vector. We examined the tumorigenicity of mIFN-? gene modified H22 in experimental animals. The results indicated that the gene modified tumor cells had less tumorigenicity than the parental tumor cells and the tumor vaccine had therapeatic effects on tumor-bearing animals.
