Augmentation of Immune Functions and Autologous Tumor Killing Activity by Kappa-Selenocarrageenan in Mice Bearing Sarcoma 180
- VernacularTitle:硒酸酯多糖增强荷瘤小鼠免疫功能和自身肿瘤杀伤活性的作用
- Author:
Hulai WEI
;
Zhengping JIA
;
Huaishun ZHAO
- Publication Type:Journal Article
- Keywords:
kappa-selenocarrageenan;
natural killer cells;
lymphokine activated killer cells;
interleukin-2;
autologous tumor killing activity;
sarcoma 180
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In order to study the enhancement of immune functions and autologous tumor-killing (ATX) activity by kappa-selenocarrageenan (KSC) in mice bearing sarcoma 180, the effects of KSC and/or Cyclophosphamide (Cy) on natural killer(NK) activity, lymphokine activated killer(LAK) activity, the production of interleukin-2 (IL-2), ATK activity and the growth of sarcoma 180 (S180) were observed. The results showed that KSC promoted NK activity, LAK activity and ATK activity in vivo, increased IL-2 production at 40mg/kg ?d x 9d. It also enhanced the antitumor action of Cy (20mg/kg?d x 9d) and offsetted the inhibition of Cy on immunocompetent cells. The ATK activity in splenocytes of SI80-bearing mice could be induced and augmented by recombinant interleukin-2 (rIL-2) in vitro. In conclution, KSC had a up-regulating effect on immune functions and ATK activity in tumor-bearing mice, therefore, can be used as a biological response modifier (BRM) in cancer biotherapy.
