The Antitumor Effects of Recombinant Human Fusion Protein GM-CSF/LIF in vitro
- VernacularTitle:rhGM-CSF/LIF融合蛋白的体外抗肿瘤效应研究
- Author:
Xuefeng ZHANG
;
Zhongliang GE
;
Liya SUN
- Publication Type:Journal Article
- Keywords:
rhGM-LIF fusion protein;
tumor cell;
inhibitory effects
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The recombinant human fusion protein GM-CSF/LIF was used to study the effects of different doses rhGM-LIF, rhGM-CSF,rhLIF,and rhGM-CSF plus rhLIF on tumor cells in our paper. The results showed that rhGM-LIF induced myeloid leukemia cells differentiation and inhibited the growth of the cells significantly. Its effect was dose-related, more significantly than rhGM-CSF,rhLIF,and rhGM-CSF plus rhLIF in some dose range. It is important that rhGM-LIF can inhibit the growth of human liver cancer cell. The rhGM-LIF might be a useful recombinant protein for tumor thera-py.
