The Roles of MHC Class I Molecule and ICAM-1 in the Induction of CTL by IL-2, IL-4 or IL-6 Gene-Transfected Tumor Vaccines
- VernacularTitle:MHCⅠ类分子及ICAM-1在IL-2、IL-4、IL-6基因转染的瘤苗在诱导CTL中的作用
- Author:
Guoyou CHEN
;
Xuetao CAO
;
Long HE
- Publication Type:Journal Article
- Keywords:
interleukin-2;
interleukin-4;
interleukin-6;
gene transfection;
tumor vaccine;
MHC class I molecule;
ICAM-1
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, the expression of MHC class I molecule and ICAM - 1 on the surface of B16 melanoma cells were observed, and their roles in the induction of CTL were investigated. The results showed that both MHC class I and ICAM - 1 expression increased after IL-2, IL-4, or IL-6 gene transfection. The splenocyte CTL activity was enhanced significantly after in vivo immunization with cytokine gene - transfected B16 melanoma cells. The CTL induction was partly inhibited by anti-ICAM-1 mAb and was completely abolished by anti-MHC class I mAb. These results suggested the increased immunogenicity of IL-2,IL-4 or IL-6 gene-transfected B16 melanoma cells may be related to the upregula-tion of ICAM-1 or MHC class I molecules after cytokine gene transfection.
