Study on Anti-Tumor Effect of Vaccination with Irradiated Tumor Cells Engineered to Secrete TNF-?
- VernacularTitle:TNF-?基因修饰瘤苗的抗肿瘤作用研究
- Author:
Yuxiao SUN
;
Tengfei ZHANG
;
Shishu CHEN
- Publication Type:Journal Article
- Keywords:
hepatoma cancer;
vaccine;
gene therapy;
tumor necrosis factor ?;
tumorigenicity;
immunogenicity
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
We compared the ability of tumorigenicity of TNF-? gene-modified and unmodified H22 tumor cells, and therapeutic functions of the irradiated cells. Results indicated that H22-TNF-? cells were less tumorigenic as compared to H22 and H22-LXSN cells. In case of treatment groups, injected with irradiated tumor vaccine in 3 or 6 days after inoculation of H22 cells, the tumor growth was suppressed.
