Effect of Anti-GCBAP on Esterase Isoenzymes Metabolism in Gastric Cancer-Bearing Nude Mice
- VernacularTitle:抗胃癌生物活性肽对荷胃癌裸鼠酯酶同工酶代谢的影响
- Author:
Qingping LIU
;
Xiulan SU
;
Meirong YAN
- Publication Type:Journal Article
- Keywords:
Anti-GCBAP;
anti-tumor effect;
esterase isoenzymes
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Abnormal elevation and abnormal isoenzyme of non-specific esterase (?-NAE) are intimately associated with the genesis and development of cancer.Anti-GCBAP is a new kind of biological response modifier(BRM) which is separated from gastric cancer cells immunized animal spleen. As determined by clonogenic assay. Anti-GCBAP displayed highly-potent, specific cytotoxicity regarding to target cancer cells. In the present study, we have further investigated the effect of Anti-GCBAP on the ?-NAE isoenzymes in gastric cancer-bearing nude mice. The results demonstrated that in vivo adminstration of Anti-GCBAP can not only inhibit tumor growth in tumor-bearing mice, compared with control(p
