Effect of batroxobin on vascular smooth muscle cell proliferation induced by balloon angioplasty in rat aorta
- VernacularTitle:东菱克栓酶对球囊损伤后大鼠主动脉血管细胞增殖的影响
- Author:
Jingbo LIU
;
Lihui WANG
;
Meng GAO
- Publication Type:Journal Article
- Keywords:
Tobishi Batroxobin Aorta Rat Smooth muscle cell
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A model of vascular smooth muscle cell proliferation was estabolished by balloon angioplas-ty in rat's aorta. We found that treatment with batroxobin decreased plasma fibrinogen level after angio-plasty, and inhibited the increase in smooth muscle cell count of injured vascular wall and incorporation rate of H-TdR into vascular tissues effectively. The results suggest that batroxobin may have clinically prospective significance in prevention and therapy of angioplasty-induced restenosis.
