Effect of Tripterygtam wilfordii Glycosides and poly saccharide sulphate on the intimal proliferation of injured rat aorta
- VernacularTitle:雷公藤多甙、藻酸双酯钠对大鼠受损动脉内膜增生的影响
- Author:
Renpeng WANG
;
Guoying ZHU
;
Lihui WANG
- Publication Type:Journal Article
- Keywords:
Intima Proliferation Tripterygium wilfordii glycosides Poly saccharide sulphate
- From:
Chinese Journal of Interventional Cardiology
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
31 rat were divided randomly into control group (n=10),tripterygium wilfordii glycosides group (n = 10 9. 4 mg/kg per day),and poly saccharide sulphate group (n=11. 30 mg/per day). We made balloon endothelium denudation in thoracic aortae of the rats. The treatments with drugs began 6 days before balloon injury and continously until the animal were killed 14 day after balloon injury. The determinations for area of neointima, neointima /media, coverage of neointima and 3H-TdR incoperation of thoracic aortae suggested that tripterygium wilfordii glycosides can inhibit intimal proliferation of injuried aorta, whill poly saccharide sulphate shows no effect.
