Bio-Distribution of IL-2 and Its Relation to the Therapeutic Effects
- VernacularTitle:IL-2的体内分布及其与疗效的关系
- Author:
Jinghua HE
;
Yan PANG
;
Ruifang NIU
- Publication Type:Journal Article
- Keywords:
interleukin-2;
technetium-99M;
bio-distribution;
therapeutic effect
- From:
Chinese Journal of Cancer Biotherapy
1996;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In this article, the plasma half life of IL-2 and its bio-distribution were studied using radio-nucleus Technetium-99M labeled IL-2. The results showed the plasma half life of IL-2 was merely 10 minutes mainly due to IL-2 distribute to its target organ such as liver, kidney etc,rather than clear out of the body. Our results indicated that IL-2 is a high organ-specific drug. It's plasma half life is short under high concentration in its target organ. So it might have advantages of high effectiveness and low whole body toxicity in treatment of tumor of liver and kidney.
