Enhancing Effects of Intraperitoneal Injection with IL-2 Recombinant Adenovirus and IL-3 Recombinant Adenovirus on the Anti-Leukemia Activity of Chemotherapy
- VernacularTitle:腹腔内注射IL-2重组腺病毒、IL-3重组腺病毒增强化疗药物抗白血病作用的研究
- Author:
Min YU
;
Xuetao CAO
;
Weiping ZHANG
- Publication Type:Journal Article
- Keywords:
Interleukin - 2 recombinant adenovirus;
Interleukin - 3 recombinant adenovirus;
gene therapy;
leukemia
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The Ad-IL-2 and/or Ad-IL-3 were i. p. injected into experimental leukemic mice after high dose chemotherapy. When Ad - LacZ was i. p. injected into leukemic mice, there were leukemic cells in bone marrow, vessal, liver and spleen. After i. p. injection of Ad-IL-2 and/or Ad-IL-3, the leukemia - bearing mice showed significant inhibition of tumor growth. As i.p. injection of Ad-IL-2, the splenic NK, CTL activity increased; as i. p. injection of Ad - IL - 3, the number and cytotoxicity of peritoneal macrophages were significantly higher than that of the control groups. After i. p. injection of Ad - IL - 2 and Ad - IL - 3 at the same time, the anti - leukemia activity was the best. Though there were less leukemic cells in the bone marrow, there were no leukemic cells in the liver and spleen. Our results suggested that i. p. injection of Ad - IL - 2 and Ad - IL - 3 could significantly enhance the anti - leukemia activity of chemotherapy.
