Combined Use of IL-2 and IL-7 Augments the in vitro Growth of T Lymphocytes with Maintenance of Functional Specificity
- VernacularTitle:联合应用IL-2和IL-7对T细胞体外增殖及功能的增强效应
- Author:
Huilian QIN
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
IL - 2;
IL - 7;
TH;
CTL;
tumor immunotherapy;
immunoregulatory
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The results of the current studies demonstrated that the combined use of IL - 2 and IL - 7 could augment the in vitro proliferative responses of tumor - specific T cell lines and clones to antigen stimulation, increasing stimulation induces 6 to 8 times greater than using either IL - 2 or IL - 7 alone. Antigen - driven T cells maintained in culture using this combined cytokine regimen can be induced to grow and maintained functional in large numbers and survive long-term in cultrue with each antigen restimulation cycle prolonged to six weeks. The IL-2 doses used in this combined cytokine regimen can be reduced 10 to 100 times that of cultures using IL-2 alone. Thus, the combined use of IL-2 plus IL-7 is effective for procuring large numbers of antigen - specific functional T cells in vitro.
