Gene Therapy of Mice Melanoma by HSV-tk/ACV System
- VernacularTitle:HSV-tk/ACV系统基因治疗小鼠黑色素瘤的实验研究
- Author:
Hong ZHANG
;
Daru LU
;
Min TAN
- Publication Type:Journal Article
- Keywords:
melanoma;
HSV-tk/ACV;
gene therapy;
Acyclovir (ACV)
- From:
Chinese Journal of Cancer Biotherapy
1995;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
This is the first report on gene therapy of mice melanoma by HSV - tk/ACV system. The sensitivity to ACV of genetically modified B16 cells (B16LNTK) was much higher than that of the parental cells. The sensitivity to ACV of B16 cells was increased when they were co - cultured with B16LNTK cells with various ratios. which showed the exist of the by stander effects. The tumor volume of B16LNTK (0.25cm3) is 94% less than that of B16 in C57BL/6 mice after 20-days ACV treatment. (P
