CARBOXYLIC DERIVATIVES OF SUBERGORGIC ACID AND THEIR TOXICOLOGY
- VernacularTitle:海洋毒素柳珊瑚酸的羧基改造及其毒理研究
- Author:
Yingcai PENG
;
Zhongde WU
;
Kanghou LONG
- Publication Type:Journal Article
- Keywords:
Coral neurotoxin;
subergorgic acid;
derivatives;
toxicology
- From:
Chinese Journal of Marine Drugs
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Six new sesquiterpenoid compounds of nerve-activity were synthesized from a gorgonian neurotoxin -subergorgic acid (1). Toxicological studies and structural correlation with toxicity reveal that subergorgic acid may act on cholinesterase and make a reversible inhibition of its activity of hydrolysis.
