The effect of Ca~(2+) preconditioning and ischemic preconditioning on Ca~(2+) paradox injury in rat Heart
- VernacularTitle:Ca~(2+)预处理和缺血预处理对大鼠心脏Ca~(2+)反常损伤的影响
- Author:
Zhengang ZHANG
;
Junhua ZHANG
;
Lihui WANG
- Publication Type:Journal Article
- Keywords:
Preconditioning Ca2+ paradox Myocardioprotection
- From:
Chinese Journal of Interventional Cardiology
1996;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Repeated calcium depletion and repletion of short term duration Ca2+ preconditioning CPC is hypothesized to protect the heart from lethal injury after exposing it to the Ca2+ paradox (Ca2+ PD). Hearts were preconditioned with five cycles of Ca2+ depletion (1 minute) and Ca2+ repletion (5 minutes). These hearts were then subjected to Ca2+ PD,ie,one cycle of Ca2+ depletion (ten minutes) and Ca2+ repletion (ten minutes). Hearts subjected to the Ca2+ PD underwent rapid and severely injury. CPC showed remarkable protection against the Ca2+ PD injury. Protein release from the perfusated heart was significantly reduced in CPC hearts compared with nopreconditioned Ca2+ PD hearts (0. 56 + 0. 10 and 1. 23 + 0. 10 mg/ml respectively ,P
