The Enhancing Effects of Fibroblast-Mediated G-CSF Gene Therapy on the Recovery of Hematopoiesis
- VernacularTitle:成纤维细胞介导的G-CSF基因疗法促进化疗后造血功能恢复的实验研究
- Author:
Quanxing WANG
;
Xuetao CAO
;
Zhengfang ZHOU
- Publication Type:Journal Article
- Keywords:
granulocyte colony - stimulating factor;
gene therapy;
fibroblast;
chemotherapy;
hematopoietic recovery
- From:
Chinese Journal of Cancer Biotherapy
1994;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, the effects of G-CSF gene therapy was investigated on the recovery of murine hematopoietic suppression induced by high dose of cyclophosphomide (Cy) . The results showed that G-CSF gene therapy could slow down the Cy-induced decreasing of peripheral WBCs and platelets, and accerelate their recovery.It also could increase the CFU-GM, CFU - MK, CFU-S derived from the splenocyte and bone marrow cells in the chemotherapy-treated mice. The data demonstrated that fibroblast-mediated G-CSF gene therapy could significantlyreduce the hematopoietic damage to less extent, and accerelate hematopoietic recovery after chemotherapy.
