EXPERIMENTAL STUDIES ON ANTITHROMBOSIS OF EICOSAPENTAENOIC ACID
- VernacularTitle:二十碳五烯酸抗拴作用的实验研究
- Author:
Xueyuan SHANG
;
Shiling ZHANG
;
Bo JIAO
- Publication Type:Journal Article
- Keywords:
Eicosapentaenoic acid (EPA);
thromboxane B2 (TXB2 );
6-ketp-PGF1a;
antithrombosis;
pialelet aggregation
- From:
Chinese Journal of Marine Drugs
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of eicosapentaenoic acid (EPA) on experimental thrombosis and its mechanism were studied. The results showed that eicosapentaenoic acid had a significant antithrombolic effect both in vivo and in vitro . EPA also had a fibrinolytic activity and can shorten euglobulin lysis time. Our studies also showed that EPA can inhibit platelet aggregation in rats. The plasma concentration of 6-keto-PGF1a and TXB2 was measured by radioimmunoassay. The results showed that EPA can reduce the contents of TXB2 and raise 6-keto-PGF1a/TXB2 ratio.
