The change of endogenous opiate peptides and monoamines in cerebral tissue after cerebral ischemia
- VernacularTitle:内啡肽和单胺类介质在脑缺血时的动态变化
- Author:
Ying PENG
;
Xingcai LIU
;
Wenqin CAI
- Publication Type:Journal Article
- Keywords:
Cerebral ischemia LEK ?-EP DynA1-13 5-HT 5-HIAA
- From:
Journal of Clinical Neurology
1995;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Rats were used to establish an animal model of cerebral ischemia and the change of endogenous opiate peptides (LEK, ?-EP, DynA1-13) and monoamines (5-HT, 5-HIAA) levels in the ischemia cerebral tissue were measured. The main findings were as follows: The levels of LEK reduced slightly in cerebral ischemia for 60 minutes, but the levels of DynA1-13 and 5-HIAA increased obviously in cerebral ischemia for 60 minutes. At the same time the levels of ?-EP and 5-HT decreased obviously. The results suggest that the endogenous opiate peptides and monomines play a possible role in the development of cerebral ischemic damage.
