Relationship Between C-erbB2 Expression and Lysis Activity of Lymphokine-Activated Killer Cells in Ovarian Cancer and in vitro Regulation by ?-Interferon
- VernacularTitle:卵巢癌细胞C-erbB_2表达与LAK杀伤活性的关系及IFN-?的体外调控影响
- Author:
Zhijun JIN
;
Xiyin ZHANG
;
Youji FEN
- Publication Type:Journal Article
- Keywords:
ovarian neoplasms;
oncogene;
lymphokine-activated killer cells;
(?)-interferon
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Using ovarian cancer cell lines, we studied relationship between C-erbB2 expression and lysis activity of lymphokine-activated killer cells (LAK) and in vitro regulation by ?-interferon (IFN-?). The results showed that C-erbB2 overexpression was associated with resistance to lysis activity of LAK in ovarian cancer; IFN-? could reduce the overexpression of C-erbB2 and increase lysis activity of LAK on ovarian cancer cells in which C-erbB2 were overexpressed.
