Experimental Study on the Adoptive Cellular Immunotherapy and Related Mechanism
- VernacularTitle:肿瘤继承性细胞免疫治疗及其机制的实验研究
- Author:
Yidi CHENG
;
Guangxia SHI
;
Baohua XUE
- Publication Type:Journal Article
- Keywords:
adoptive cellular immunotherapy;
L615 murine leukemia;
LAK cell
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Using a syngeneic transplantable leukemia model of 615 inbred mice, named L615, we (1) compared the adoptive immunoprophylactic(AIP) effects of spleen cells from various normal dornor mice with different genetic background and from different immune-deficient mice;(2) studied the adoptive immunotherapeutic (AIT) and adoptive chemo-immunotherapeutic(ACIT) effects of immune spleen cells from those survival mice in the AIP groups;(3) analysed the antitumor activities of various murine spleen cells either nonspecifically activated in vitro or specifically induced in vivo and resensitized in vitro by MMC-treated L615 tumor cell vaccine (TCV).Our results might provide some new experimental evidences for clinical application of cancer ACI.
