Effect of IL-2 Gene Therapy on Immune and Hematopoietic Reconstitution after Bone Marrow Transplantation
- VernacularTitle:IL-2基因疗法对骨髓移植后免疫及造血重建的影响
- Author:
Qin LI
;
Xuetao CAO
;
Quanxin WANG
- Publication Type:Journal Article
- Keywords:
interleukin-2;
gene therapy;
bone marrow transplantation;
immunity;
hematopoietic reconstitution
- From:
Chinese Journal of Cancer Biotherapy
1995;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present study, the effect of fibroblast-mediated IL-2 gene therapy on immune and hematopoietic reconstitution was observed after syngeneic bone marrow transplantation (BMT) in the mice which had received high-dose chemotherapy. The NK activity , LAK activity and the proliferation of BMT were augmented significantly , while there were no effects on the formation of CFU-GM, CFU-MK and CFU-E of bone marrow after IL-2 gene therapy. The results suggested that fibroblast-mediated IL-2 gene therapy can accelerate and prompt the process of immune reconstitution, then enchance the antitumor effect and reduce the complication such as infection after BMT. The experiment provide basis for the application of IL-2 gene therapy in BMT in the future.
