The effect of different concentrations of glucose with or without hyperlipidemic serum on the cytomorphology of arterial smooth muscle cells
- VernacularTitle:葡萄糖与高脂血清对动脉平滑肌细胞结构的影响
- Author:
Jie SHEN
;
Jiawei CHEN
;
Quanzhi LIU
- Publication Type:Journal Article
- Keywords:
Glucose Hyperlipidemic serum Cytomorphology of smooth muscle cells
- From:
Chinese Journal of Diabetes
1994;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The observations on cytomorphology and cytodynamics of cultured rabbit arterial smooth muscle cells(SMC)under concentrations of glucose 5.55,11.1,16.7,33.4 and 55.5 mmol/L with or without hyperlipidemic serum(HLS)were carried out by light microscopy and transmission election microscopy. The results showed that①The extent of disruption in SMC was positively correlated with concentrations of glucose,and negatively correlated with the multipication ralte of DNA,a parameter of cytodynamics.②There was no synergistic effect between glucose and HLS in the development of atherosclerosis.③In high glucose concentration groups(glucose 16.7mmol/L)a calcifies particle of high electronic density like substance,probably the core of atherosclerosis was found in SMC. Our results suggest that to keep lower levels of blood glucose and blood lipids may delay the development of atherosclerosis.
