STUDIES ON TOTAL SYNTHESIS AND STRUCTURE——ACTIVITY RELATIONSHIP OF MARINE ALGA ANTIBIOTIC( - ) -MALYNGOLID IV synthesis of 5 - hydroxymethyl - 5 - benzyl - s -valerolactone
- VernacularTitle:海藻抗生素(一)-Malyngolide类似物5-羟甲基-5-苄基戊内酯的合成
- Author:
Heping ZENG
- Publication Type:Journal Article
- Keywords:
valerolactone;
marine antibiocic analoque;
chiral phase transfer catalyst
- From:
Chinese Journal of Marine Drugs
1994;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Title compund have been synthesized from adipic acid (starting material ) in six steps, a chiral phase transfer catalyst (3s,4s)-1-benzyle-1-methyl-3,4 - pyrrolidindiol-onium iodide (PTC) was used to promote the iasymmetric reactions in the key steps of forming chiral centers
