IMMUNOELECTRON-MICROSCOPIC LOCALIZATION OF A 54-kDa PROTEIN OVEREXPRESSED BY CHLOROQUINE-RESISTANT PLASMODIUM BERGHEI ANKA STRAIN
- VernacularTitle:抗氯喹伯氏疟原虫ANKA株过度表达的54 kDa蛋白免疫电镜定位
- Author:
Gaode LI
;
Fengyi QU
;
Shuqin LIU
- Publication Type:Journal Article
- Keywords:
malaria ,Plasmodium berghet, drug resistance, chloroquine .immunoelectron microscopy
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
A 54-kDa protein overexpressed by chloroquine-resistant Plasmodium berghei ANKA strain was first reported by us. In this paper, the localization of this protein by immunoelec-tron microscopy is presented. The results showed that the protein was mainly scattered inside the cytoplasm of the early date trophozoites and schizonts of erythrocytic stage of P. berghei ANKA strain , and some of it was also found in cytoplasm of erythrocytes infected with parasites. The protein content was much higher in chloroquine-resistant P. berghei ANKA strain than in chloroquine-sensitive P. berghei ANKA strain, suggesting the importance of this protein in understanding mechanism of chloroquine resistance in malaria parasites .
