A population association study of glucokinase gene and non-insulin-dependent (type 2) diabetes mellitus in Chinese
- VernacularTitle:葡萄糖激酶基因与中国人非胰岛素依赖型糖尿病的群体关联研究
- Author:
Kunsan XIANG
- Publication Type:Journal Article
- Keywords:
Non-insulin-dependent diabetes mellitus Genes Glucokinase
- From:
Chinese Journal of Diabetes
1993;0(00):-
- CountryChina
- Language:Chinese
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Abstract:
The association of glucokinase(GCK) gene with type 2 diabetes in Chinese was studied by using the polymerase-chain-reaction amplified microsatellite polymorphism marker, GCK-5'. In comparison with non-diabetics,allele 4 was significantly increased in type 2 diabetics(X2 = 6. 773,P=0. 009). The frequency of genotype 44 and 4X was significantly higher in type 2 diabetics than in non-di-abetics(X2 = 6. 439, P = 0.011). The allelic frequency difference was also observed in overweight/obese subgroup compariscn(X2 = 7. 718,P = 0. 021). The risk of type 2 diabetes in Chinese with genotype 44 or 4X is about 3. 6 times higher than in Chinese with genotype XX. Our results indicate that GCK is associated with type 2 diabetes in Chinese.
