IN VITRO DEVELOPMENT OF SODIUM ARTESUNATE RESISTANCE IN PLASMODIUM FALCIPARVM
- VernacularTitle:恶性疟原虫对青蒿酯钠抗性的体外培育
- Author:
Gangfeng JIANG
- Publication Type:Journal Article
- Keywords:
Plasmodium falciparum,antimalarials,artesunate,drug resistance.
- From:
Chinese Journal of Parasitology and Parasitic Diseases
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Plasmodium falciparum(Lab.culture FCR3 isolate) developed resistance to sodium artesunate after exposure to the drug in vitro.The drug effective concentration which resulted in 50 per cent schizont maturation inhibition (IC50) was 1.6ng/ml (4.1nmol/L) before exposure to the drug.After 130 days of discontiguous exposure to sodium artesunate in a stepwise fashion,the sensitivity of the isolate to the drug decreased,with its IC50 3-fold higher than that of the parent isolate.The resistance to artesunate decreased significantly after the resistant line was grown in drug-free medium.
