Effects of CL 316243 on isolated term-pregnant rat myometrial strips in vitro
- VernacularTitle:CL 316243对孕大鼠离体子宫平滑肌收缩的作用
- Author:
Fei YAN
- Publication Type:Journal Article
- Keywords:
?3-adrenoreceptor;
CL316243;
Salbutamol;
cAMP
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of the selective ?3-adrenoreceptor (AR) agonist,CL 316243,on the contractions and levels of cAMP and cGMP of myometrial strips isolated from term-pregnant rats.Methods:Salbutamol,an agonist of ?2-AR,was chosen as positive control.We evaluated the effect of increasing concentrations of CL 316243 and salbutamol on oxytocin-induced myometrialcontractions with or without metoprolol,ICI 118.551 and SR 59230A.Effects of CL 316243 and salbutamol on cAMP and cGMP levels in isolated myometrial strips were also evaluated by radioimmunoassay.Results:CL 316243 concentration-dependently decreased the amplitude of oxytocin-induced contractions with Emax value(48.13%?5.61%)ofCL316243,whichwas significantlylargerthanEmaxvalue(35.52%?5.15%)ofsalbutamol(P
