Pharmacokinetics of probucol self-microemulsifying drug delivery system in rats
- VernacularTitle:普罗布考自微乳化释药系统大鼠体内药动学研究
- Author:
Lili MA
- Publication Type:Journal Article
- Keywords:
Probucol;
Self-microemulsifying drug delivery system;
HPLC;
Pharmacokinetics
- From:
Journal of Chongqing Medical University
2007;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the pharmacokinetics of probucol(PB)self-microemulsifying drug delivery system(PB-SMEDDS) in rats.Methods:Rats were used as the models.With PB suspension as control,double cycle crossover with single oral dose was performed to investigate the pharmacokinetics of PB-SMEDDS.The HPLC method was established to detect drug concentration in the rat plasma,and the obtained data were processed with 3P97 software.Results:The plasma concentration-time profiles of PB-SMEDDS conformed to a two-compartment model(the coefficient weight is 1/C2).Cmax,tmax and AUC0～96h were 6.72?g/ml,8.58 h and 253.98(?g.h)/ml,respectively.The AUC0～96h of PB-SMEDDS was 19.08 times of PB suspension.Conclusion:PB-SMEDDS could improve the oral bioavailability of PB significantly.
