Immuno-therapeutic effect of Interleukin-2 in HIV-1 infection
- VernacularTitle:HIV-1感染中的白介素-2免疫治疗作用
- Author:
Yi REN
;
Ke ZHANG
- Publication Type:Journal Article
- Keywords:
HIV;
Antiretroviral therapy;
Interleukin-2
- From:
Chinese Journal of AIDS & STD
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Antiretroviral therapy(ART)has been started in an increasingly earlier period in clinical practice.However,owing to the failure of immunological reconstitution or maintenance of latent HIV-1 reservoir in present antiviral treatment,interleukin-2(IL-2)is widely used as an adjuvant to ART with a view to intensifying immunological reconstitution and to activating latent HIV-1 infections.Some conclusions could be drawn as follows,1)IL-2 can extend the half-life of CD+4 T cells and increase the number of CD+4 T cells.2)Compared with ART alone,IL-2 and HAART combination can not reduce HIV-1 related opportunistic infection or death.IL-2 clinical usage is mainly focused on purging HIV-1 reservoir.3)IL-2 combined with ART could increase out flow rate of HIV-1 latent reservoir to reduce HIV-1 infected quiescent memory cells in peripheral circulation even to an undetectable level.4)IL-2 is supposed to be used periodically and for a long period of time.
