Preparation and in vitro evaluation of dispersible tablet of total notoginseng saponin
- VernacularTitle:三七总皂苷分散片的制备及其体外评价
- Author:
Sha HAN
;
Yunfeng ZHU
;
Qingri CAO
;
Jinghao CUI
- Publication Type:Journal Article
- Keywords:
total notoginseng saponin;
dispersible tablet;
in vitro;
evaluation
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To establish the preparative method of dispersible tablet of total notoginseng saponin (DTTNS) by powder direct compression,and to evaluate it pharmaceutical characteristics. METHODS: The effect of factors on the disintegration of DT-TNS was investigated by single factor method,and the formulation was optimized through orthogonal design. RESULTS: The disintegration time of DT-TNS containing 40% total notoginseng saponin was within 1 min while the formulation mainly consisted of 49% MCC as filler,12% of PVPP mixed with 3% L-HPC as disintegrating agent. In addition,the dissolution of DT-TNS was almost finished in 10-15 min. CONCLUSION: The preparative method of DT-TNS by powder direct compression is simple,with short disintegration time and high dissolution rate.
