Influencing factors of the formulation and preparation on in vitro drug release from sinomenine hydrochloride delayed-onset sustained-release tablet
- VernacularTitle:盐酸青藤碱延迟起释型缓释片释药的处方和工艺影响因素
- Author:
Yanna GENG
;
Yu ZHANG
- Publication Type:Journal Article
- Keywords:
sinomenine hydrochloride;
delayed-onset sustained-release;
in vitro drug release;
tablet
- From:
Chinese Traditional Patent Medicine
1992;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To study the formulation and preparation factors on vitro drug release from sinomenine hydrochloride delayed-onset sustained-release tablet. METHODS: With hydrophilic matrix materials as excipient,the tablets containing hydrochloride sinomenine as a model drug were prepared by direct compression. The effect of the type and amount of tablet core matrix materials(HPMC K15M,HPMC K4M,xanthan gum and carrageenan),the type and amount of coating matrix materials,the preparation of coating materials and the pressure on in vitro drug release of the tablets were studied. RESULTS: The lag time of the tablet was 4 ～ 5 h and drug release slowly in 24 h. The type and the amount of the core matix materials and the coating matrix materials play an important role on lag time and drug release(P
