Preparation of osmotic pump-controlled release tablets of total flavones in Lysimachia clethroides
- VernacularTitle:珍珠菜总黄酮渗透泵控释片的制备研究
- Author:
Bengang YOU
;
Haimin PAN
;
Qiongming XU
;
Lihua TANG
;
Shilin YANG
- Publication Type:Journal Article
- Keywords:
total flavones of Lysimachia clethroides Duby;
osmotic pump-controlled release tablets;
uniform design
- From:
Chinese Traditional and Herbal Drugs
1994;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare osmotic pump-controlled release tablets of total flavones in Lysimachia clethroides.Methods Two components of the extract from L.clethroides,rutin and naringenin-7-O-glucoside were used to evaluate the release behavior of osmotic pump controlled release tablets.Single factor investigation was carried out on the membrane compositions and orifice variables,and uniform design was used to optimize the formulation of coating mambrane.Results The membrane weight,PEG400 content,and dibutyl phthalote(DBP) content were the main factors influencing the drug release,and based on 45% and 8.5% of cellulose acetate,respectively,to prepare osmotic pump-controlled release tablets could achieve the desired zero-order release profile.Conclusion The formulation and technology are simple and easy to be carried out.Osmotic pump-controlled release tablets have a stable drug release bahavior and a good reproducibility.
