Muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge is associated with cervical lymph node metastasis.
10.5125/jkaoms.2016.42.3.133
- Author:
Seung Ki MIN
1
;
Hoon MYOUNG
;
Jong Ho LEE
;
Myung Jin KIM
Author Information
1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Seoul National University, Seoul, Korea. myoungh@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Oral squamous cell carcinoma;
Mandibular alveolar ridge;
Muscle invasion;
Cervical lymph node metastasis
- MeSH:
Alveolar Process*;
Antibodies;
Biopsy;
Carcinoma, Squamous Cell*;
Epithelial Cells*;
Humans;
Lymph Nodes*;
Lymphatic Vessels;
Magnetic Resonance Imaging;
Mandible;
Muscles;
Neoplasm Metastasis*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
2016;42(3):133-138
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: To assess the association between muscle invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis on the basis of preoperative magnetic resonance imaging (MRI). MATERIALS AND METHODS: Twenty-six patients with oral squamous cell carcinoma of the posterior mandibular alveolar ridge were evaluated by MRI. The associations between cervical lymph node metastasis and independent factors evaluated by MRI were analyzed. Overall survival was also analyzed in this manner. Representative biopsy specimens were stained with anti-podoplanin and anti-CD34 antibodies. RESULTS: Mylohyoid muscle invasion was associated with cervical lymph node metastasis. A combinational factor of mylohyoid and/or buccinator muscle invasion was also associated with cervical lymph node metastasis. Cervical lymph node metastasis and masticator space invasion had a negative effect on overall survival. No lymphatic vessels were identified near the tumor invasion front within the mandible. In contrast, lymphatic vessels were identified near the front of tumor invasion in the muscles. CONCLUSION: This study demonstrates an association between muscular invasion by oral squamous cell carcinoma of the posterior mandibular alveolar ridge and cervical lymph node metastasis.
