Neonatal vitamin A and LRAT is affected in marginal vitamin A deficiency rats
- VernacularTitle:孕期边缘性维生素A缺乏对新生大鼠VA营养及LRAT的影响
- Author:
Jian HE
- Publication Type:Journal Article
- Keywords:
Vitamin A;
Liver;
Rat;
Retinol;
Retinyl ester;
Marginal vitamin A deficiency(MVAD);
Lecithin retinol acyltransferase(LRAT)
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of neonatal vitamin Aand LRAT in marginal vitamin Adeficiency(MVAD)rats during pregnancy.Methods:Sixteen adult female Wistar rats were randomly separated into control and MVAD groups (eight per group).Serum and livers from mothers and new borns were collected after the establishment of the above two animal models.The vitamin A level was analyzed by HPLC.RT-PCR and Western blot analysis were used to assay the transcriptional level and protein level of LRAT in neonatal liver.Results:The plasma and liver vitamin A level from maternal and neonatal was significantly lower in the MVAD compared to the control group (P
