Single nucleotide polymorphisms 936C/T,-460T/C,405G/C in vascular endothelial growth factor gene and their association with cerebral infarction
- VernacularTitle:血管内皮生长因子936C/T、-460T/C、405G/C单核苷酸多态性与脑梗死的关系
- Author:
Tianlian LI
- Publication Type:Journal Article
- Keywords:
Vascular endothelial growth factor;
Single nucleotide polymorphisms;
Cerebral infarction
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the relationship between the single nucleotide polymorphisms (SNP)936C/T,-460T/C,405G/C in Vascular endothelial growth factor (VEGF)gene and their association with cerebral infarction (CI).Methods:Case-control study was carried out to investigate allelic genotypes and frequency of the three VEGF SNP in 150 subjects with CI and 120 control individuals.Polymerase chain reaction-Restriction fragment lengthpolymorphism,(PCR-RFLP)[U3] and DNA sequencing were used to analyze the polymorphisms.The correlations between VEGF SNPs and CI were evaluated.Results:There was a highly significant difference in allele frequency of 936C/T SNP between CI and control subjects,and the T allele frequencies were respectively 0.3667 versus 0.2500(P
