The clinical significance of p16~(INK4a) in cervical cytology staging
- VernacularTitle:p16~(INK4a)在子宫颈细胞学分级的临床意义
- Author:
Xuan HUANG
- Publication Type:Journal Article
- Keywords:
p16INK4a;
HPV16/18;
Cervical cytology
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression and significance ofp16INK4a and HPV16/18 in atypical squamous cells of undetermined significance(ASC-US),atypical squamous cells,cannot exclude high-grade squamous intraepithelial lesion(ASC-H),low-grade squamous intraepithelial lesion(LSIL),high-grade squamous intraepithelial lesion(HSIL).Methods:p16INK4a and HPV16/18 DNA in thin-layer slides from 89 specimens were detected by immunohistochemistry and the insitu hybridization.Results:A positive correlation was found between the positive rate of p16INK4a and cervical disease progression,the positive rate of p16INK4a in LSIL,HSIL,ASC-H were higher than ASC-US(P
