Seroepidemiology of Hepatitis A in Korea: Changes over the Past 30 Years.
10.3346/jkms.2011.26.6.791
- Author:
Hyunju LEE
1
;
Hye Kyung CHO
;
Jong Hyun KIM
;
Kyung Hyo KIM
Author Information
1. Department of Pediatrics, Ewha Womans University School of Medicine, Seoul, Korea. kaykim@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatitis A;
Seroepidemiologic Studies
- MeSH:
Adolescent;
Adult;
Age Factors;
Aged;
Child;
Child, Preschool;
Female;
Hepatitis A/*epidemiology/immunology;
Hepatitis A Antibodies/blood;
Humans;
Infant;
Male;
Middle Aged;
Republic of Korea/epidemiology;
Seroepidemiologic Studies
- From:Journal of Korean Medical Science
2011;26(6):791-796
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study aimed to assess the immune status of the Korean population against hepatitis A virus (HAV). Residual serum samples from 2008 to 2010 were collected from diagnostic laboratories and a total of 1,872 samples were analyzed. Anti-HAV seroprevalence was 57.3% in subjects aged 1-4 yr, 69.8% at 5-9 yr and decreased to 38.8% at 10-14 yr, 13.0% at 15-19 yr, and 11.7% at 20-29 yr. Seroprevalence increased with increasing age: 52.2% at 30-39 yr, 83.2% at 40-49 yr, 81.4% at 50-59 yr, 93.2% at 60-69 yr, and 95.1% at 70-79 yr. The most susceptible age group consisted of subjects aged 10-29 yr, especially those aged 20-29 yr. This pattern is markedly different from that in the past 3 decades, where the most susceptible group had consisted of children aged less than 10 yr and almost all subjects aged more than 20 yr had developed anti-HAV antibodies. Because of improvements in hygiene and introduction of hepatitis A vaccine, the age demographic of the susceptible population has shifted. These data are important for creating new prevention measures, including vaccination policies, to prevent and control outbreaks of hepatitis A in Korea.
