Study on the preparation and in vitro release characteristics of super paramagnetic isoniazid sulfate-loaded PELA microsphere
- VernacularTitle:超顺磁性异烟肼聚乙二醇-聚乳酸共聚物微球制备工艺及体外药物释放研究
- Author:
Heng ZHOU
- Publication Type:Journal Article
- Keywords:
Isoniazid;
PELA;
Super paramagnetic microspheres;
Oscillating magnetic fields
- From:
Journal of Chongqing Medical University
2007;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To prepare super paramagnetic SPI-loaded PELA microsphere,study its release characteristics in vitro with the effect of oscillating magnetic fields.Methods:The nanospheres of super paramagnetic were prepared by chemical coprecipitation and then the super paramagnetic SPI-loaded PELA microspheres were prepared by double-emulsion/solvent evaporation method.Some factors affecting preparation technic,such as concentration of PVA,PELA concentration,speed of viscolizer and so on were studied.In addition, the drug release of super paramagnetic SPI-loaded PELA microsphere with the effect of oscillating magnetic fields was studied.Results: Factors for the optimal preparation technic included:speed of viscolizer of 13 000 r/min,inter water phase/oil phase of 1/20,volume ratio of water and magnetic fluid in inter water phase of 1/2,PELA concentration of 40 mg/ml,ultrasonic efficiency of 600 W,concentration of PVA of 1.5%.Oscillating magnetic field could improve the speed of drug release.Conclusion:Super paramagnetic SPI-loaded PELA microsphere were successfully prepared according to double-emulsion/solvent evaporation method.SPI-PELA-MS had the characteristics of sustained-release.The oscillating magnetic fields could promote drug release of SPI-PELA-MS.
