Relationship of Phlegm and Blood-stasis Syndrome in Coronary Heart Disease with Gene Polymorphism of Apolipoprotein E
- VernacularTitle:冠心病痰瘀证候与载脂蛋白E基因多态性相关性的研究
- Author:
Honghui MO
;
Peiguang PAN
;
Yanshou HUANG
;
Yongdun HONG
;
Yanhong WANG
- Publication Type:Journal Article
- Keywords:
CORONARY DISEASE;
APOLIPOPROTEIN E;
GENE POLYMORPHISM;
PHLEGM AND BLOOD-STASIS SYNDROME
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of apolipoprotein E(ApoE) and its gene polymorphism with phlegm and blood stasis syndrome in patients with coronary heart disease(CHD).Methods Ninety-seven qualified CHD patients involving phlegm syndrome(PS),blood-stasis syndrome(BSS),and phlegm and blood stasis syndrome(PBSS) were adopted.Thirty-five healthy volunteers were enrolled into the control group.Serum ApoE level was examined in all of the subjects,and their whole blood DNA were extracted for the detection of ApoE gene polymorphism by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).Correlation analysis of the data was performed with SPSS11.0 software.Results The difference of diabetes mellitus,smoking,low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) was significant between CHD patients and healthy volunteers(P
