Study on Inactivation of Viruses in Intravenous Immunoglobulin Preparation by Pasteurization
- VernacularTitle:静脉注射免疫球蛋白加热处理灭活病毒的研究
- Author:
Jingxing WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Blood Transfusion
1988;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
An intravenous immunoglobulin preparation(IVIG)in solution was pasteurized,or heated at 60℃ for 10 hours in the presence of 50g/dl xylitol as stabilizer.The results show- ed that the antibody levels against diphtheria,measles viruses and HBs Ag,of the pasteurized IVIG,were not changed,the Fc function of IgG molecule was not damaged,the anti- complement activity was reduced significantly,and its stability was improved.Both model viruses,the cytomegalovirus and the simian retrovirus D1,added in the prepara- tion,were inactivated rapidly under the above-mentioned conditions as those of IVIG pasteurization.It was suggested that the pasteurized IVIG preparation not only fully saved its biological activity,but also would be better tolerance for intravenous injection and the safety in preven- tion of viral disease transmission.
