Study on Encapsulation Efficiency and In-vitro Release of Glycyrrhetinic Acid Liposomes
- VernacularTitle:甘草次酸脂质体的包封率测定和体外释放度考察
- Author:
Yi CHENG
;
Bohong GUO
;
Lping LIN
- Publication Type:Journal Article
- Keywords:
GLYCYRRHETINIC ACID/production & preparation;
LIPOSOMES;
IN-VITRO RELEASE;
CHROMATOGRAPHY,HIGH PRESSURE LIQUID
- From:
Journal of Guangzhou University of Traditional Chinese Medicine
2000;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the encapsulation efficiency of glycyrrhetinic acid(GA) liposomes and to study the release of GA from the liposomes in vitro.Methods GA liposomes were prepared by ethanol injection.The unencapsulated glycyrrhetinic acid and liposomes were separated by sephadex gel G-50,and the encapsulation efficiency was detected by HPLC.The release behavior of the drug was studied by the third method for dissolution issued in Chinese pharmacopoeia(published in 2005).Results The encapsulation efficiency of liposomes was 91.61%,and the in-vitro drug-release curve was accorded with Higuchi equation.Conclusion The GA liposomes have high encapsulation efficiency and sustained-release effect.
