Prostate Volume has Prognostic Value Only in Pathologic T2 Radical Prostatectomy Specimens.
10.3346/jkms.2011.26.6.807
- Author:
In Chang CHO
1
;
Whi An KWON
;
Jeong Eun KIM
;
Jae Young JOUNG
;
Ho Kyung SEO
;
Jinsoo CHUNG
;
Weon Seo PARK
;
Kang Hyun LEE
Author Information
1. Department of Urology, Center for Prostate Cancer, National Cancer Center, Goyang, Korea. uroonco@ncc.re.kr
- Publication Type:Original Article
- Keywords:
Prostate;
Prostatic Neoplasms;
Prostatectomy;
Volume
- MeSH:
Aged;
Aged, 80 and over;
Follow-Up Studies;
Humans;
Kaplan-Meier Estimate;
Male;
Middle Aged;
Neoplasm Recurrence, Local/diagnosis;
Neoplasm Staging;
Organ Size;
Predictive Value of Tests;
Prostate/*pathology;
Prostate-Specific Antigen/blood;
Prostatectomy;
Prostatic Neoplasms/*pathology/surgery;
Retrospective Studies;
Risk Factors
- From:Journal of Korean Medical Science
2011;26(6):807-813
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to evaluate the prognostic roles of the prostate volume, tumor volume, and tumor percentage as a function of the pathologic T stage in radical prostatectomy specimens. This study included 259 patients who underwent radical prostatectomy between 2005 and 2010. The mean follow-up period was 41.2 months. In all of the specimens, prostate volume (P = 0.021), the Gleason score (P = 0.035), and seminal vesicle invasion (P = 0.012) were independent predictors of biochemical recurrence (BCR). In the T2 group, multivariate analysis showed that the BCR was significantly associated with prostate specific antigen (PSA) (P = 0.028), a lower prostate volume (P = 0.004), and the Gleason score (P = 0.040). The Kaplan-Meier survival curve showed that a smaller prostate volume was significantly associated with a greater risk of BCR (< 30 vs > or = 30 mL; P = 0.010). In the T3 group, patients with seminal vesicle invasion had a significantly shorter mean BCR-free survival (P = 0.030). In this study, tumor volume and tumor percentage did not predict BCR. Notably, a lower prostate volume is an independent predictor for BCR only in the organ-confined radical prostatectomy specimens. But, prostate volume could not predict BCR in most locally advanced tumors.
