Optimization of total epimediumon flavone microporosity osmotic pump tablet formulation by box-behnken design and response surface methodology
- VernacularTitle:Box-Behnken设计-效应面法优化淫羊藿总黄酮微孔渗透泵片处方
- Author:
Ping WEI
;
Rongli YIN
;
Dongfen LI
;
Shengqi WU
;
Jinyu CHEN
- Publication Type:Journal Article
- Keywords:
total epimediumon flavone;
microporosity osmotic pump tablet;
box-behnken design and response surface methodology
- From:
Chinese Traditional Patent Medicine
1992;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To optimize total flavone of herba epimediumon microporosity osmotic pump tablets by boxbehnken design-response surface methodology. METHODS:Osmotic agent (lactose),dosage of plastificator (dibutyl phthalate),and coating weight gain were selected as key factors of influencing total flavone delivery. Total flavones cumulatiive yield in 12 h and fitting approximation was regarded as the response. Design Expert method useful for the modeling and analysis was to optimize the response. RESULTS:Response surface surface obtained repre-sented maximum one which conformed to the zero-order delivery rate equation. CONCLUSION:Optimal excipient formulation of total epimedium flavone microporosity osmotic pump tablet consists of 0. 18 g of lactose,0. 26 ratio of dibutyl phthalate to acetyl celulose and 7. 7% of coating weight gain.
