Waldenstrom Macroglobulinemia with CD5+ Expression Presented as Cryoglobulinemic Glomerulonephropathy: A Case Report.
10.3346/jkms.2011.26.6.824
- Author:
You Lim KIM
1
;
Soo Jung GONG
;
Young Hwan HWANG
;
Jong Eun JOO
;
Young Uk CHO
;
Jung Ae LEE
;
Su Ah SUNG
;
So Young LEE
;
Nae Yoo KIM
Author Information
1. Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea. gsj1117@eulji.ac.kr
- Publication Type:Case Report
- Keywords:
Waldenstrom Macroglobulinemia;
CD5+ Lymphoplasmacytic Lymphoma;
Cryoglobulinemic Glomerulonephritis
- MeSH:
Antigens, CD5/*metabolism;
Antineoplastic Agents/therapeutic use;
B-Lymphocytes/immunology/metabolism;
Bone Marrow/pathology;
Cryoglobulinemia/diagnosis;
Cyclophosphamide/therapeutic use;
Diagnosis, Differential;
Doxorubicin/therapeutic use;
Drug Therapy, Combination;
Female;
Glomerulonephritis/*diagnosis/pathology;
Humans;
Kidney/pathology;
Middle Aged;
Paraproteinemias/diagnosis;
Prednisolone/therapeutic use;
Vincristine/therapeutic use;
Waldenstrom Macroglobulinemia/*diagnosis/drug therapy/pathology
- From:Journal of Korean Medical Science
2011;26(6):824-828
- CountryRepublic of Korea
- Language:English
-
Abstract:
Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.
