A new-type non-adhesive thermosensitive liquid embolic agent for the embolization of cerebral arteriovenous malformation:an experimental study
- VernacularTitle:新型温敏性栓塞剂用于脑动静脉畸形实验研究
- Author:
Shaosheng WANG
;
Wenkun ZHANG
;
Jie DONG
- Publication Type:Journal Article
- Keywords:
thermosensitivity;
embolic agent;
arteriovenous malformation;
intervention
- From:
Journal of Interventional Radiology
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To synthesize a new-type thermosensitive liquid embolic material and to investigate the feasibility of using this material to occlude cerebral arteriovenous malformations (AVMs).Methods The copolymer was synthesized with N-isopropylacrylamide (NIPAM) and N-n-propylacrylamide (NNPAM),and it's physical and biological properties were estimated.The embolization of AVMs model in vitro by using this copolymer was conducted and the results were analyzed.Results The new-type copolymer possessed unique thermal behavior of lower critical soluble temperature (LCST),and it was water-soluble and non-adhesive with better biocompatibility.The successful embolization of AVMs model could be reliably obtained.Conclusion The copolymer synthesized by the authors is a new-type liquid embolic agent suitable for endovascular embolization of cerebral AVMs in vitro.Based on the results in experiment animals having been reported in medical literature,this copolymer can be further used in clinical research.
