Lineage Switch at Relapse of Childhood Acute Leukemia: A Report of Four Cases.
10.3346/jkms.2011.26.6.829
- Author:
Meerim PARK
1
;
Kyung Nam KOH
;
Bo Eun KIM
;
Ho Joon IM
;
Seongsoo JANG
;
Chan Jeoung PARK
;
Hyun Sook CHI
;
Jong Jin SEO
Author Information
1. Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jjseo@amc.seoul.kr
- Publication Type:Case Report
- Keywords:
Lineage Switch;
Acute Leukemia
- MeSH:
Acute Disease;
Bone Marrow/pathology;
Cell Lineage;
Child;
Chromosome Aberrations;
Female;
Hematopoietic Stem Cell Transplantation;
Humans;
Immunophenotyping;
Infant;
Leukemia, Myeloid, Acute/*diagnosis/drug therapy/pathology;
Male;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/*diagnosis/drug therapy/pathology;
Recurrence;
Salvage Therapy;
Transplantation, Homologous
- From:Journal of Korean Medical Science
2011;26(6):829-831
- CountryRepublic of Korea
- Language:English
-
Abstract:
Lineage switch in acute leukemia is an uncommon event at relapse, and therefore rarely reported in the literature. Here, we have described the clinical laboratory features of four cases in which the cell lineage switched from acute lymphoblastic leukemia (ALL) to acute myeloid leukemia (AML). One patient was initially diagnosed with B-ALL, switched to T-ALL at the first relapse, and eventually, AML at the second relapse. A lineage switch represented either relapse of the original clone with heterogeneity at the morphologic level or emergence of a new leukemic clone. Further sequential phenotypic and cytogenetic studies may yield valuable insights into the mechanisms of leukemic recurrence, with possible implications for treatment selection.
