The effects of radix astragali on hypertrophic scars in rabbit ears
- VernacularTitle:黄芪对兔耳增生性瘢痕作用的实验研究
- Author:
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Radix astragali;
Hypertrophic scar;
TGF-?1
- From:Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effects of radix astragali on hypertrophic scars in rabbit ears. Methods:Twenty healthy adult Japanese big ear rabbits were given hypertrophic scars over the ventral surface of the ears and on the 21st day after wound,animals were randomly divided into the treated groups (groups A,B,and C were treated with radix astragali in different concentrations)and the control groups(groups D and E were treated with saline and blank control,respectively). On the 32nd and 43rd day after wound,the thickness and hardness of scar were measured.The TGF-?1mRNA were detected in hypertrophic scar samples with RT- PCR.The change of scar tissues was observed with H&E staining and immunohistochemical staining with TGF-?1. Results:The thickness and hardness of scar were inversely correlated with the concentration of radix astragali in the radix astragali-treated group(P0.05)between the 32nd day and43rd day groups.Conclusion:Radix astragali could inhibit proliferation of hypertrophic scars in the rabbit ears by decreasing the expression of TGF-?1mRNA and its protein. Thereby radix astragali may have beneficial effects in the treatment of hypertrophic scar.
