Effects of polycylic aromatic hydrocarbons on plasma monoamine neurotransmitters
- VernacularTitle:多环芳烃类对人群血浆中单胺类神经递质的影响
- Author:
Lijun HE
- Publication Type:Journal Article
- Keywords:
Polycylic aromatic hydrocarbons;
Benzo[a]pyrene;
1-hydroxypyrene;
Monoamine neurotransmitters
- From:
Journal of Chongqing Medical University
2003;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of polycylic aromatic hydrocarbons (PAHs)on plasma monoamine neurotransmitters. Methods:80 healthy adult male coke oven workers were selected from a coke plant of a state-owned steel enterprise,80 controls were selected from the oxygen factory. Concentration of benzo[a]pyrene(B[a])P in the working environment was monitored by high performance liquid chromatography(HPLC)with fluorescence detector. The level of urinary 1-hydroxypyrene(1-OHP)was determ ined by HPLC with fluorescence detector.The plasma noradrenaline(NE),adrenaline(AD),dopamine(DA)and serotonin(5-HT)levels were measured by high performance liquid chromatography (HPLC) with electrochemical detection. Results:In the working environment of B[a]P, concentration in coke oven workers were significantly higher than controls (P
